A quantum-chemical approach to develop tetrahydroquinoxaline as potent ferroptosis inhibitors

WHY AND HOW TO APPLY QUANTUM LEARNING AS A NEW APPROACH TO IMPLEMENTATION THE CURRICULUM

The present study was philosophical and analytical research that examines quantum learning as an effective approach to the curriculum in a qualitative way. It explored books, published essays, and related studies, and took some advantages of online materials on the issue from domestic and foreign sources. Because of large body of data on the issue, only the relevant information was included. Da...

new pantacyclic tacrines as potent acetylcholinesterase inhibitors

A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis

Discovering compounds and mechanisms for inhibiting ferroptosis, a form of regulated, nonapoptotic cell death, has been of great interest in recent years. In this study, we demonstrate the ability of XJB-5-131, JP4-039, and other nitroxide-based lipid peroxidation mitigators to prevent ferroptotic cell death in HT-1080, BJeLR, and panc-1 cells. Several analogues of the reactive oxygen species (...

Quantum chemical assessment of benzimidazole derivatives as corrosion inhibitors

BACKGROUND The majority of well-known inhibitors are organic compounds containing multiple bonds and heteroatoms, such as O, N or S, which allow adsorption onto the metal surface. These compounds can adsorb onto the metal surface and block active surface sites, reducing the rate of corrosion. RESULTS A comparative theoretical study of three benzimidazole isomers, benzimidazole (BI), 2-methylb...

2,4-Diaminopyrimidines as Potent Inhibitors of Trypanosoma brucei and Identification of Molecular Targets by a Chemical Proteomics Approach

BACKGROUND There is an urgent need to develop new, safe and effective treatments for human African trypanosomiasis (HAT) because current drugs have extremely poor safety profiles and are difficult to administer. Here we report the discovery of 2,4-diaminopyrimidines, exemplified by 4-[4-amino-5-(2-methoxy-benzoyl)-pyrimidin-2-ylamino]-piperidine-1-carboxylic acid phenylamide (SCYX-5070), as pot...